Models for plasma metabolite correction

Models for describing the fraction of labeled metabolites in plasma are developed mainly to 1) remove noise in the measured fractions, 2) to allow interpolation of the fraction between the few metabolite samples, 3) to allow extrapolation of the fraction in cases where metabolite fraction can no longer be determined because of low activity counts, and 4) to allow the application of population based average metabolite correction. This document reviews the models that are used to correct the plasma time-activity curves (TACs) for labeled metabolites in PET measurements.